SKUALUM KAITA
Shark Cartilage is a controversial natural product, effective placebo for some and for others, about which in the past thirty years eminent scientists have conducted and published more than a few laboratory studies. It also has a considerable number of successful experiences and their use involves little or no risk for most adults. Its importance is that it can be used to complement conventional treatments to inhibit the growth of tumors and other degenerative diseases associated with aging.
Pharmacological properties of shark cartilage
Antiangiogenic ActionShark cartilage is able to act at different stages of neovascularization:- Inhibits the proliferation of endothelial cells by blocking competitively "Endothelial Growth Factor (EGF)" to its endothelial receptor level. It also inhibits tyrosine phosphorylation dependent on the receiver FCE FCE-2 and increased permeability induced by EGF. This prevents the initiation of cell division and blood vessel formation.- Induces apoptosis of endothelial cells, contains a factor that induces proapoptotic activation of caspases 3, 8 and 9 and the release of cytochrome c from mitochondria to cytoplasm, resulting in endothelial apoptosis.- Fibrinolytic activity: Increases the secretion, activity and affinity for plasminogen "tissue plasminogen activator (tPA)" by the endothelial cells. TPA is a serine protease that breaks into the clot plasminogen to generate plasmin, which in turn digests fibrin and dissolves the clot. This causes localized destruction of the fibrin provisional matrix required for vascular neoformation.- Inhibits the degradation of the extracellular matrix: an important process in the formation of new blood vessels and tumor cell dissemination. Endothelial cells secrete growth matrix metalloproteinases capable of digesting extracellular matrix and allow blood vessels to invade the area to provide nutrients to the tumor. Shark cartilage inhibits matrix metalloproteinases MMP-2, MMP-7, MMP-9, MMP-12 and MMP-13.- Stimulates the production of angiostatin, a plasminogen-derived protein that inhibits blood vessel growth in tumors and has been shown to inhibit metastasis in animal models.
Antitumor Action
- Slows tumor growth and reduced tumor size.- Inhibition of metastasis.- Increases the cytotoxic effects of chemotherapy (cisplatin).- Reduce adverse effects of chemotherapy (cisplatin).Immunomodulatory actionIncreases intratumoral T cell infiltration and the relationship CD (4) / CD (8). His Proteoglycans are potent stimulators of macrophages and lymphocytes B.
Shark Cartilage is a controversial natural product, effective placebo for some and for others, about which in the past thirty years eminent scientists have conducted and published more than a few laboratory studies. It also has a considerable number of successful experiences and their use involves little or no risk for most adults. Its importance is that it can be used to complement conventional treatments to inhibit the growth of tumors and other degenerative diseases associated with aging.
Pharmacological properties of shark cartilage
Antiangiogenic ActionShark cartilage is able to act at different stages of neovascularization:- Inhibits the proliferation of endothelial cells by blocking competitively "Endothelial Growth Factor (EGF)" to its endothelial receptor level. It also inhibits tyrosine phosphorylation dependent on the receiver FCE FCE-2 and increased permeability induced by EGF. This prevents the initiation of cell division and blood vessel formation.- Induces apoptosis of endothelial cells, contains a factor that induces proapoptotic activation of caspases 3, 8 and 9 and the release of cytochrome c from mitochondria to cytoplasm, resulting in endothelial apoptosis.- Fibrinolytic activity: Increases the secretion, activity and affinity for plasminogen "tissue plasminogen activator (tPA)" by the endothelial cells. TPA is a serine protease that breaks into the clot plasminogen to generate plasmin, which in turn digests fibrin and dissolves the clot. This causes localized destruction of the fibrin provisional matrix required for vascular neoformation.- Inhibits the degradation of the extracellular matrix: an important process in the formation of new blood vessels and tumor cell dissemination. Endothelial cells secrete growth matrix metalloproteinases capable of digesting extracellular matrix and allow blood vessels to invade the area to provide nutrients to the tumor. Shark cartilage inhibits matrix metalloproteinases MMP-2, MMP-7, MMP-9, MMP-12 and MMP-13.- Stimulates the production of angiostatin, a plasminogen-derived protein that inhibits blood vessel growth in tumors and has been shown to inhibit metastasis in animal models.
Antitumor Action
- Slows tumor growth and reduced tumor size.- Inhibition of metastasis.- Increases the cytotoxic effects of chemotherapy (cisplatin).- Reduce adverse effects of chemotherapy (cisplatin).Immunomodulatory actionIncreases intratumoral T cell infiltration and the relationship CD (4) / CD (8). His Proteoglycans are potent stimulators of macrophages and lymphocytes B.
Anti-inflammatory effect has been attributed to its high content of mucopolysaccharides, mainly chondroitin sulfates A, C and D, which modulate the production of cytokines (induce the expression of IL-10 and IFN gamma).In murine models, shark cartilage reduced the inflammatory response that accompanies the crisis of bronchial asthma. It also blocks the increase in vascular permeability induced by histamine.Antioxidant-antimutagenic actionShark cartilage is unique to capture and eliminate free radicals, especially superoxide radical, thus ensuring a protective effect against injury at the DNA level.
Analgesic Action
An extract of shark cartilage, particularly a soluble fraction is used in the treatment of pain in patients with prostate cancer and metastatic breast, obtaining good results.The mechanism of action of this soluble fraction has been at the level of nitric oxide synthesis.
Animal studies have shown the effect of shark cartilage glycosaminoglycans to lower cholesterol levels, LDL and VLDL, which results in a decreased risk of atherosclerosis (effect attributed to chondroitin 6-sulfate).Clinical Utility Shark Cartilage
Phase III clinical trials in patients with lung cancer (non-small-cell) and renal cell carcinoma, and phase II in patients with multiple myeloma refractory or relapsed, which has demonstrated increased survival.
The orally administered shark cartilage hinders angiogenesis and significantly reduces swelling and immobility and joint pain, an effect that occurs due in part to the large amount of mucopolysaccharides containing and act along with protein inhibitors of angiogenesis, a synergistic effect in preventing further destruction of cartilage. In addition, the dual action of cartilage: stimulation of the immune system and inhibiting the formation of new blood vessels, does not impede other therapies that are dramatic or simple and, most importantly, shark cartilage has none of the side effects themselves of the drugs most commonly used.Research has proven that can reduce pain by 70% of cases of osteoarthritis and 60% of rheumatoid arthritis.
Enteritis
It has also been used successfully oral administration of shark cartilage to inflammation of the bowel mucosa or regional enteritis, people gain weight, energy and better mood.In other studies of people affected by Candida albicans enteritis responded quickly after the ingestion of shark cartilage, which also achieves very good responses in other types of intestinal inflammation.
Retinal Problems
The formation of new blood vessels in the retina is one of the mechanisms underlying retinal several problems that can lead to blindness such as diabetic retinopathy, macular degeneration, vein occlusion or retinal circulation.Inhibition of angiogenesis by Shark Cartilage retinal level could help reduce the progression of the disease in these patients.
Skin problems
A randomized phase I / II in 49 patients with psoriasis reported significant improvement. These results are explained by the inhibition of neovascularization of psoriatic plaques.Preparations have been applied to cartilage, also successful in patients with allergies or irritations stinging plants, and other skin disorders like acne and pruritus ani.
Contraindications
Avoid the use of shark cartilage in the following conditions:- Patients with heart problems.- Pregnant women, as is building a network of blood vessels to nourish the developing fetus, or women who wish to become mothers because the cartilage may hinder the vascularization during the menstrual cycle.- Patients undergoing major surgery for new blood vessels needed to speed healing, or who is an intensive program of liposculpture.- Children of the blood vessels being still under development.
Interactions
Shark cartilage may contain high doses of calcium and can dangerously elevate calcium levels in the blood if taken with drugs known to increase the calcium in the blood. For example, the prolonged use of thiazide diuretics such as chlorothiazide (Diuril ®). In theory, the effect of shark cartilage may add to the effects of drugs and experimental agents that block the growth of new blood vessels. According to animal studies, the anticancer drug cisplatin and shark cartilage can be used together against tumors, although there is no reliable
evidence of human use.Little evidence suggests that shark cartilage may lower blood sugar. Caution is advised when using medications that can lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by qualified medical personnel and may require adjustments in medication.
Kaita Skualum
Presentation: Capsules: 120 und bottle x 350 mg .Recommended Dosage:- Adults: 1 to 2 capsules after each meal.Rheumatic problemsCancerHypolipidemic actionAnti-inflammatory Action
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PRICE 1 BOTTLE: 20 USD
PRICE 2 BOTTLES: 35 USD
PRICE 5 BOTTLES: 80 USD
PRICE 10 BOTTLES: 140 USD
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